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Naltrexone in the treatment of alcohol dependence. A deficit in inhibitory restraint i. CP, a selective, non-peptide antagonist of the corticotropin-releasing factor1 receptor attenuates stress-induced relapse to drug seeking in cocaine- and heroin-trained rats. Pharmacologic manipulations of these receptor systems have proven of some utility in drug treatment, and several new approaches are in development. Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain. December ; [Abstract no.

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Because inhalant overdose can lead to seizures or cause the heart to stop, first responders and emergency room doctors try to treat the overdose by treating these conditions.

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Erb S, Stewart J. The attenuated D2 striatal concentrations were hypothesized to lessen the reinforcing salience of natural rewards and to heighten the need for substance-induced elevations in dopaminergic efflux. However, whereas these brain regions demonstrate increased regional brain activation relative to controls during craving induction, they generally show decreased activation relative to controls during other activating tasks see above. The amygdala is implicated in the acquisition, storage, and expression of emotional memories. Imaging endogenous dopamine competition with [11C]raclopride in the human brain.

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